The affected person transplanted with a genetically modified pig kidney dies | Science | EUROtoday

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Richard Slayman, seated, with the Massachusetts General Hospital team before returning home last April.
Richard Slayman, seated, with the Massachusetts General Hospital staff earlier than returning dwelling final April.MGH

Richard Slayman, the primary particular person to be transplanted with a genetically modified pig kidney, has died on the age of 62, virtually two months after present process xenotransplantation, using cells, tissues or organs from animals to implant them in a human recipient. Massachusetts General Hospital and Salyman's household reported the demise this previous Saturday, though the medical heart claims to haven’t any indication that it was because of the transplant.

The demise has annoyed the forecasts of the medical staff, which hoped that the xenotransplantation might work for 2 years. Slayman, born in Weymouth, Massachusetts, was the primary residing particular person to bear the process, which has failed on different events as a result of the human immune system destroys the overseas animal tissue. In truth, the method was beforehand examined on two individuals with pig hearts and with the same outcome.

David Bennett lived for 2 months with a genetically altered pig coronary heart in his chest and died in March 2022. Lawrence Faucette, 58, died final November after receiving a transplant with comparable traits in September. Both suffered from a terminal coronary heart situation and have been positioned within the palms of the University of Maryland Medical Center in Baltimore.

Slayman had acquired a human kidney six years in the past, but it surely was rejected by his physique and he needed to bear frequent dialysis. It was then that the affected person accepted the proposal of receiving the organ from a genetically modified pig.

“I am excited to once again spend time with my family, friends and loved ones without the burden of dialysis that has affected my quality of life for many years. “Today is a new beginning not only for me, but also for them,” mentioned Slayman final April, after receiving permission to comply with the evolution at dwelling and in reference to sufferers who rely on a transplant.

In a press release, Slayman's household thanked the docs for his or her work: “Their enormous efforts in leading the xenotransplant gave our family seven more weeks with Rick. [Richard] and the memories created during that time will remain in our minds and hearts.”

They have additionally highlighted the worth of Slayman in going through the novel therapeutic proposal to advance an answer for 1000’s of sufferers. “Rick achieved that goal and his hope and optimism will last forever,” says the textual content from his household.

As of December 31, 2023, the ready checklist to obtain an organ in Spain stood at 4,790 sufferers, 75 of them youngsters. The determine is much like that of 2022, which closed with 4,746 individuals on the ready checklist.

Last 12 months, 3,688 kidney transplants have been carried out in Spain (8% greater than the earlier 12 months), 1,262 liver transplants (+9%), 479 lung transplants (+15%), 325 coronary heart transplants (+5%), 100 pancreas transplants (+9%). %) and seven intestinal (+75%).

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